Science

Revigenics Senolytic Max™ – Scientific Rationale 

Product: Revigenics Senolytic Max™ – Cellular Detox Formula
Format: 300 mg Fisetin • 200 mg Quercefit® Quercetin Phytosome • 10 mg Piperlongumine • 5 mg BioPerine®
Use: 1 capsule twice daily for 2 consecutive days per month (senolytic “pulse” dosing)

1. Science Overview

Senescent “zombie” cells accumulate with age and secrete inflammatory factors (the SASP), contributing to joint discomfort, tissue stiffness, metabolic decline, and accelerated aging. Senolytics are compounds that help the body selectively clear these cells, often using short, intermittent (“hit-and-run”) dosing rather than daily megadoses. Europe PMC+1

Revigenics Senolytic Max™ is built around:

  • Clinically explored senolytic flavonoids (fisetin, quercetin)
  • A highly bioavailable quercetin phytosome (Quercefit®) with ~20× better absorption vs standard quercetin NutraIngredients.com+1
  • Piperlongumine, a potent senolytic candidate in preclinical research
  • BioPerine®, a proven bioavailability enhancer that can increase absorption of polyphenols and other actives by 30–200%+PMC+1

The goal is precision dosing: enough to matter, not so much that it stresses the liver, gut, or drug metabolism.

2. Ingredient Rationale

1) Fisetin – 300 mg per capsule (600 mg/day; 1,200 mg per 2-day cycle)

  • Identified as a powerful senotherapeutic in mice and human tissues, improving health and lifespan. Europe PMC
  • The Mayo group proposed a 20 mg/kg fisetin protocol (≈1,400 mg/day for a 70 kg adult) for 2 consecutive days, repeated monthly, and it has been widely referenced in the longevity community. Fight Aging!
  • Revigenics uses a moderate fisetin dose per capsule, but combined with enhanced bioavailability and synergy (quercetin phytosome + piperine) to reduce the need for an extreme gram-level dose.

2) Quercefit® Quercetin Phytosome – 200 mg per capsule (400 mg/day)

  • Standard quercetin has very low oral bioavailability (<1%). Wikipedia
  • Quercefit® uses Indena’s Phytosome® technology (quercetin + sunflower lecithin) and has been shown in human pharmacokinetic studies to be up to 20-fold more bioavailable and well tolerated. NutraIngredients.com+1
  • This means 400 mg/day of Quercefit® can deliver plasma exposure similar to several grams of regular quercetin — with better tolerability.

3) Piperlongumine – 10 mg per capsule (20 mg/day)

  • A natural alkaloid from Piper longum studied as a senolytic candidate; it increases oxidative stress selectively in senescent cells, pushing them toward apoptosis in preclinical work. ScienceDirect
  • There is not yet robust human dosing data, so Revigenics uses a conservative 20 mg/day to capture synergy without taking the untested 50 mg/day route some competitors use.

4) BioPerine® – 5 mg per capsule (10 mg/day)

  • Piperine, the active in BioPerine®, is the original “bioenhancer” and has been shown to increase the bioavailability of multiple compounds (curcumin, resveratrol, beta-carotene, CoQ10, drugs, etc.) by 30–200%. PMC+1
  • It works mainly by slowing metabolism and efflux (e.g., via CYP3A4 and P-gp modulation), giving fisetin and quercetin more “time in circulation” to act. ScienceDirect+1

3. Mechanistic Synergy

Mechanistically:

  • Fisetin – Core senolytic flavonoid; promotes apoptosis in senescent cells and reduces SASP factors. Europe PMC
  • Quercetin Phytosome – Senolytic + anti-inflammatory; synergizes with fisetin and supports endothelial and immune health. PubMed+1
  • Piperlongumine – Preclinical senolytic that increases ROS stress in senescent cells and disrupts survival pathways. ScienceDirect
  • BioPerine® – Raises circulating levels of co-ingredients so you can achieve desired effects with lower, safer doses. PMC+1

This combination is designed as a focused senolytic triad, not a giant “kitchen sink” blend.

4. Dosing Rationale – Why 2 Days per Month?

Senolytic research in humans and animals supports intermittent, pulse dosing, not continuous daily exposure:

  • Fisetin 20 mg/kg given on 2 consecutive days monthly (the “Mayo fisetin protocol”) is the most commonly cited senolytic schedule. Fight Aging!+1
  • A 2024 RCT using dasatinib + quercetin in postmenopausal women also used intermittent senolytic pulses rather than daily dosing. PubMed

Revigenics follows that logic:

Use Senolytic Max™ for 2 consecutive days per month (1 capsule twice daily with meals), giving a strong but time-limited senolytic stimulus while allowing the body to recover between cycles.

5. Safety Positioning

Revigenics intentionally stays:

  • Below or within human-studied senolytic ranges for fisetin
  • Uses bioavailable forms of quercetin and a gentle piperine dose
  • Avoids estrogenic soy isoflavones, large multi-herb combinations, and untested megadoses
  • Aligns with a “clinical-precision, safety-first” longevity philosophy, consistent with your brand values

“We optimize how much gets into your bloodstream, not how big the milligram number looks on the label.”