Revigenics Senolytic Max™ – Scientific & Clinical Reference Brief
For healthcare professionals and science-minded customers

1. Senolytic & Senomorphic Concept

• Cellular senescence contributes to age-related decline via the SASP inflammatory secretome.

• Preclinical studies show that clearing senescent cells (senolysis) or suppressing their harmful secretions (senomorphics) improves health span. ScienceDirect

2. Fisetin – Core Senolytic Flavonoid

• Identified as a potent senotherapeutic in mice and human tissues, improving health and lifespan even with late-life intervention. Europe PMC
• A commonly referenced protocol (the “Mayo fisetin protocol”) uses 20 mg/kg oral fisetin on 2 consecutive days, repeated monthly. Fight Aging!

• Ongoing human trials are evaluating fisetin for metabolic, inflammatory, and age-related outcomes. ClinicalTrials+1

3. Quercetin Phytosome (Quercefit®) – Enhanced Bioavailability & Senolytic Synergy

• Standard quercetin has very poor oral bioavailability, often under 1%. Wikipedia
• Quercefit® (Indena) is a quercetin Phytosome® formulation shown in human studies to be up to 20× more bioavailable than unformulated quercetin and well tolerated. NutraIngredients.com+1
• Intermittent senolytic therapy with dasatinib + quercetin has been clinically tested in postmenopausal women, showing effects on bone metabolism and validating the senolytic hit-and-run concept in humans. PubMed

4. Piperlongumine – Preclinical Senolytic Candidate

• Piperlongumine selectively increases oxidative stress in senescent cells, impairing their survival pathways (e.g., BCL-2 family, NRF2, PI3K) in preclinical models. ScienceDirect
• Human dosing and long-term safety data are still limited; therefore, Revigenics uses a conservative 10 mg per capsule (20 mg/day) level designed for synergy, not solo effect.

5. BioPerine® (Piperine) – Bioavailability Enhancer

• Piperine is recognized as a classic bioenhancer, increasing the bioavailability of many compounds by 30–200% by inhibiting metabolizing enzymes and efflux transporters. PMC+1
• Clinical studies show piperine can increase curcumin absorption up to ~20×, illustrating the principle. PMC+1

6. Intermittent Senolytic Dosing in Humans

• Intermittent (“pulsed”) senolytic dosing has been explored with both fisetin and dasatinib + quercetin, supporting the rationale for 2-day monthly protocols rather than continuous daily supplementation. Fight Aging!+1

These statements have not been evaluated by the FDA. Senolytic Max™ is a dietary supplement intended to support healthy aging and cellular health. It is not intended to diagnose, treat, cure, or prevent any disease. Clinical data cited refer to individual ingredients or related senolytic protocols, not to this finished product as a drug.